Analysis of Nucleoside Analogs as Antimicrobials Focusing on Distinctive Enzymes in Borrelia burgdorferi
The primary line remedy for Lyme illness is remedy with doxycycline, amoxicillin, or cefuroxime. In endemic areas, the persistence of signs in lots of sufferers after completion of antibiotic remedy stays a serious healthcare concern.
The causative agent of Lyme illness is a
heavy metals and enzyme train in soils all through the zone of have an effect on of various
e auxotroph that can’t exist below free-living situations and relies upon upon the tick vector and mammalian hosts to satisfy its dietary wants.
Regardless of missing all main biosynthetic pathways, B. burgdorferi uniquely possesses three homologous and practical methylthioadenosine/S-adenosylhomocysteine nucleosidases (MTANs: Bgp, MtnN, and Pfs) concerned in methionine and purine salvage, underscoring the vital function these enzymes play within the life cycle of the spirochete.
At the very least one MTAN, Bgp, is outstanding in its presence on the floor of Lyme spirochetes and its twin performance in nutrient salvage and glycosaminoglycan binding concerned in host-cell adherence.
Thus, MTANs supply extremely promising targets for discovery of recent antimicrobials. Right here we report on our research to guage 5 nucleoside analogs for MTAN inhibitory exercise, and cytotoxic or cytostatic results on a bioluminescently engineered pressure of B. burgdorferi. All 5 compounds had been both alternate substrates and/or inhibitors of MTAN exercise, and diminished B. burgdorferi development.
Two inhibitors: 5′-deoxy-5′-iodoadenosine (IADO) and 5′-deoxy-5′-ethyl-immucillin A (dEt-ImmA) confirmed bactericidal exercise. Thus, these inhibitors exhibit excessive promise and kind the inspiration for improvement of novel and efficient antimicrobials to deal with Lyme illness.

![]() PGFM Enzyme Immunoassay kit (One Plate) |
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K022-H1 | Arbor Assays | 1x96 well plate | EUR 354 |
![]() PGFM Enzyme Immunoassay kit (Five Plate) |
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K022-H5 | Arbor Assays | 5x96 well plate | EUR 664 |
![]() SARS-CoV-2 Antigen Rapid Test Kit (Colloidal gold Immunoassay) |
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CoV2Ag-25 | Elabscience Biotech | 25 Tests/Kit | EUR 35 |
Description: This SARS-CoV-2 Antigen Rapid Test Kit (Colloidal Gold) uses the sandwich immunocapture method and colloidal gold immunochromatography to qualitatively determine the presence of SARS-CoV-2 antigens in human oropharyngeal swabs, nasal swabs and nasopharyngeal swabs. It is helpful as an aid in the screening of early mild, asymptomatic, or acute patients for identification of SARS-CoV-2 infection. |
![]() RealScreen HSV-2 IgG ELISA Kit |
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EL022-096 | GenDepot | 96T | EUR 712 |
![]() Cortisol Enzyme Immunoassay kit - 1 Strip plate |
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K003-H1 | Arbor Assays | 1x96 well plate | EUR 311 |
![]() Cortisol Enzyme Immunoassay kit - 1 Whole plate |
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K003-H1W | Arbor Assays | 1x96 well plate | EUR 305 |
![]() Cortisol Enzyme Immunoassay kit - 5 Strip plates |
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K003-H5 | Arbor Assays | 5x96 well plate | EUR 1055 |
![]() Cortisol Enzyme Immunoassay kit - 5 Whole plates |
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K003-H5W | Arbor Assays | 5x96 well plate | EUR 1055 |
![]() Anti-SARS-CoV-2 Neutralization Antibody Test Kit (Colloidal gold immunoassay) |
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CP04010 | UnScience | 25T/kit | Ask for price |
Description: The Anti-SARS-CoV-2 Neutralization Antibody Test Kit (Serum/Plasma/Whole blood) is a qualitative membrane-based immunoassay for the detection of SARS-CoV-2 neutralizing antibodies in serum, plasma and whole blood. The sample is dropped into the sample well, and chromatography is performed under the capillary effect. The SARS-CoV-2 neutralizing antibodies in the sample combined with the colloidal gold-labeled SARS-CoV-2 spike protein(SP), then spread to the test area. It is captured by coated SP subunit RBDNTD-CTD, to form a complex and gather in the test area (T line). The quality control area is coated with mouse anti-chicken IgY, and the colloidal goldlabeled chicken IgY is captureed to form a complex and aggregate in hte quality control area (C line). If the C line does not show color, it indicates that the result is invalid, and this sample need to be tested again. |
![]() Human IgG AssayLite Fluorescent Immunoassay Kit |
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FEI7200 | AssayPro | 96 Well Plate | EUR 396 |
![]() LH (Luteinizing Hormone) ELISA test |
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2 | Biobase | 96T/Box | Ask for price |
Description: ELISA based test for quantitative detection of LH (Luteinizing Hormone) |
![]() NATtrol Zika Virus Stock (Qualitative) (1 mL) |
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TEST | Zeptometrix | 1 mL | EUR 1106.64 |
Description: Please contact Gentaur in order to receive the datasheet of the product. |
![]() HSV-1 IgG ELISA Kit |
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E4680-100 | Biovision | EUR 539 |
![]() HSV-?(Herpes Simplex Virus ?AntibodyIgM) ELISA test |
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37 | Biobase | 96T/Box | Ask for price |
Description: ELISA based test for quantitative detection of HSV-?(Herpes Simplex Virus ?AntibodyIgM) |
![]() Human HSV-2 IgG ELISA Kit (Direct EIA) |
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EK7060 | BosterBio | 96wells/kit, with removable strips. | EUR 478 |
![]() Human Estrone-3-Glucuronide (E1G)Enzyme Immunoassay ELISA Kit |
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QY-E05423 | Qayee Biotechnology | 96T | EUR 361 |
![]() RealScreen HSV-1 IgG ELISA Kit |
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EL020-096 | GenDepot | 96T | EUR 712 |
![]() Accu-Tell COVID-19 IgG/IgM Rapid Test |
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GEN-B352-40tests | Accu test | 40 tests | EUR 321 |
Description: A rapid test for detection of antibodies (IgG and IgM) for 2019-nCoV, the novel Coronavirus from the Wuhan strain. The test is easy to perform, takes 10 minutes to provide reliable results and is higly specific to the 2019-nCoV Coronavirus. |
![]() HSV-?(Herpes Simplex Virus ?Antibody IgM) ELISA test |
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35 | Biobase | 96T/Box | Ask for price |
Description: ELISA based test for quantitative detection of HSV-?(Herpes Simplex Virus ?Antibody IgM) |
![]() Ibrutinib drug-Human IgG Conjugate |
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IBT17-IgG | Alpha Diagnostics | 100 ug | EUR 529 |
![]() HDV-IgG hepatitis D IgG ELISA test |
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88 | Biobase | 96T/Box | Ask for price |
Description: ELISA based test for quantitative detection of HDV-IgG hepatitis D IgG |
![]() HSV Grade 2 |
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DAG-H10363 | Creative Diagnostics | 1 ml dry ice | EUR 1105 |
![]() Immunoassay Stabilizer |
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85R-103 | Fitzgerald | 1 liter | EUR 481 |
Description: Stabilizing buffer for use in immunoassays |
![]() COVID-19 IgG/IgM Rapid Test Kit |
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UNCOV-20 | UnScience | 20T/kit | EUR 155 |
![]() Human Toxoplasma (TOX) IgG Rapid Test Kit |
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abx092098-20tests | Abbexa | 20 tests | EUR 217 |
![]() Human Anti-Herpes Simplex Virus 2 IgG (HSV-2 IgG) ELISA kit, 96 tests, Quantitative |
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3300-390-H2G | Alpha Diagnostics | 1 kit | EUR 590 |
![]() HSV-2 IgM ELISA Kit |
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E4683-100 | Biovision | EUR 539 |
![]() Cystatin C Immunoassay Kit |
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K012-H1 | Arbor Assays | 1x96 well plate | EUR 405 |
![]() 11,12-DHET Immunoassay Kit |
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DH4 | Detroit R&D | 1 Kit | EUR 307 |
![]() Anti-SARS-CoV-2 Neutralization Antibody Test Kit (Enzyme-linked immunosorbent assay) |
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CP04012 | UnScience | 96T/5*96T | Ask for price |
Description: It is a semi quantitative competition ELISA kit to detect the Anti-SARS-CoV-2 Neutralization Antibody in human serum or plasma. The micro test plate provided in this kit is pre-coated with recombinant human ACE2. During the reaction, the SARS-CoV-2 neutralization antibody in the standard & sample diluent pretreated samples or controls competes with a fixed amount of human ACE2 on the solid phase supporter for sites on the Horseradish peroxidase (HRP) conjugated recombinant SARS-CoV-2 RBD fragment (HRP-RBD). After 37℃incubation, the unbound HRP-RBD as well as any HRP-RBD bound to non-neutralization antibody will be captured on the plate and eventually form the ACE2-RBD-HRP complex, while the circulating neutralization antibodies HRP-RBD complexes remain in the supernatant and are removed during washing. Then a TMB substrate solution is added to each well. The enzyme-substrate reaction is terminated by the addition of stop solution and the color change is measured spectrophotometrically at a wavelength of 450 nm ± 2 nm. |
![]() HEV-IgG CE Hepatitis E IgG ELISA test |
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91 | Biobase | 96T/Box | Ask for price |
Description: ELISA based test for quantitative detection of HEV-IgG CE Hepatitis E IgG |
![]() Human Cytomegalovirus Antibody IgG (Anti-CMV IgG) Rapid Test Kit |
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abx092099-20tests | Abbexa | 20 tests | EUR 217 |
![]() Human HSV-1 IgG ELISA Kit (Direct EIA) |
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EK7058 | BosterBio | 96wells/kit, with removable strips. | EUR 478 |
![]() Human Cytomegalovirus IgG / IgM, Toxoplasma IgG / IgM, Rubella IgG Rapid Test Kit |
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abx092078-20tests | Abbexa | 20 tests | EUR 342 |
![]() Human IgA, IgG and IgM AssayLite Multiplex Fluorescent Immunoassay Kit |
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FI700161M3 | AssayPro | 96 Well Plate | EUR 1227 |
![]() Anti-Glycoprotein B (HSV-1/HSV-2) Purified |
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11-330-C025 | ExBio | 0.025 mg | EUR 90 |
![]() Anti-Glycoprotein B (HSV-1/HSV-2) Purified |
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11-330-C100 | ExBio | 0.1 mg | EUR 140 |
![]() ANA Antinuclear Ab IgG ELISA test |
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115 | Biobase | 96T/Box | Ask for price |
Description: ELISA based test for quantitative detection of ANA Antinuclear Ab IgG |
![]() ACA Anticardiolipin Ab IgG ELISA test |
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124 | Biobase | 96T/Box | Ask for price |
Description: ELISA based test for quantitative detection of ACA Anticardiolipin Ab IgG |
![]() COX (Coxsackievirus Antibody IgG) ELISA test |
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140 | Biobase | 96T/Box | Ask for price |
Description: ELISA based test for quantitative detection of COX (Coxsackievirus Antibody IgG) |
![]() CMV (Cytomegalovirus Antibody IgG) ELISA test |
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28 | Biobase | 96T/Box | Ask for price |
Description: ELISA based test for quantitative detection of CMV (Cytomegalovirus Antibody IgG) |
![]() RV (Rubella Antibody IgG) ELISA test |
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30 | Biobase | 96T/Box | Ask for price |
Description: ELISA based test for quantitative detection of RV (Rubella Antibody IgG) |
![]() TOX (Toxoplasma Antibody IgG) ELISA test |
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32 | Biobase | 96T/Box | Ask for price |
Description: ELISA based test for quantitative detection of TOX (Toxoplasma Antibody IgG) |
![]() ANA (Antinuclear Antibody IgG) ELISA test |
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52 | Biobase | 96T/Box | Ask for price |
Description: ELISA based test for quantitative detection of ANA (Antinuclear Antibody IgG) |
![]() ACA (Anticardiolipin Antibody IgG) ELISA test |
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59 | Biobase | 96T/Box | Ask for price |
Description: ELISA based test for quantitative detection of ACA (Anticardiolipin Antibody IgG) |
![]() HSV-2 GG-2 Antibody |
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abx023687-05mg | Abbexa | 0.5 mg | EUR 537 |
![]() HSV 2 GD Protein |
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abx060595-1mg | Abbexa | 1 mg | EUR 1852 |
![]() HSV 2 GG Protein |
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abx060596-1mg | Abbexa | 1 mg | EUR 1852 |
![]() HSV-2 gG Protein |
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abx061404-1mg | Abbexa | 1 mg | EUR 940 |
![]() HSV-1 & 2 Antibody |
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abx023035-1ml | Abbexa | 1 ml | EUR 565 |
![]() Recombinant HSV-2 Protein |
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VAng-Lsx0296-inquire | Creative Biolabs | inquire | Ask for price |
Description: HSV type 2, recombinant protein from E6 cells. |
![]() Inactivated HSV-2 Antigen |
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VAng-Lsx04592-1mg | Creative Biolabs | 1 mg | EUR 531 |
Description: HSV Type 2 Antigen (Strain G) is inactivated by Photochemical treated. |
![]() Human Hepatitis A Virus IgG Rapid Test Kit |
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abx092012-25tests | Abbexa | 25 tests | EUR 425 |
![]() Human Chlamydia Pneumoniae (CP) IgG Rapid Test Kit |
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abx092079-20tests | Abbexa | 20 tests | EUR 258 |
![]() Human Mycoplasma Pneumoniae (MP) IgG Rapid Test Kit |
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abx092081-20tests | Abbexa | 20 tests | EUR 258 |
![]() Human Mycobacterium Tuberculosis (MT) IgG Rapid Test Kit |
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abx092084-20tests | Abbexa | 20 tests | EUR 230 |
![]() Human Helicobacter Pylori (HP) IgG Rapid Test Kit |
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abx092090-20tests | Abbexa | 20 tests | EUR 230 |
![]() Human Hantavirus (HV) IgM / IgG Rapid Test Kit |
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abx092094-20tests | Abbexa | 20 tests | EUR 272 |
![]() Human Rubella Virus (RV) IgG Rapid Test Kit |
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abx092097-20tests | Abbexa | 20 tests | EUR 217 |
![]() Human Rabies Virus (HRV) IgG Rapid Test Kit |
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abx092100-20tests | Abbexa | 20 tests | EUR 342 |
![]() Human Anti-Herpes Simplex Virus 1+2 IgG (HSV-1/2 IgG) ELISA kit, 96 tests, Quantitative |
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3300-400-12G | Alpha Diagnostics | 1 kit | EUR 590 |
![]() RealScreen HSV-2 IgM ELISA Kit |
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EL023-096 | GenDepot | 96T | EUR 712 |
![]() Human ACE2(Angiotensin-converting enzyme 2) ELISA Kit |
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EH0027 | FN Test | 96T | EUR 524.1 |
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 0.234 ng/ml |
![]() Rat Ace2(Angiotensin-converting enzyme 2) ELISA Kit |
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ER0609 | FN Test | 96T | EUR 567.6 |
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Rattus;Sensitivity: 0.094 ng/ml |
![]() Recombinant HSV HSV-2 gB Protein, His, E.coli-100ug |
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QP12342-100ug | EnQuireBio | 100ug | EUR 218 |
![]() Recombinant HSV HSV-2 gB Protein, His, E.coli-1mg |
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QP12342-1mg | EnQuireBio | 1mg | EUR 1261 |
![]() Recombinant HSV HSV-2 gB Protein, His, E.coli-500ug |
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QP12342-500ug | EnQuireBio | 500ug | EUR 663 |
![]() Recombinant HSV HSV-2 gD Protein, GST, E.coli-100ug |
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QP12343-100ug | EnQuireBio | 100ug | EUR 218 |
![]() Recombinant HSV HSV-2 gD Protein, GST, E.coli-1mg |
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QP12343-1mg | EnQuireBio | 1mg | EUR 1061 |
![]() Recombinant HSV HSV-2 gD Protein, GST, E.coli-500ug |
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QP12343-500ug | EnQuireBio | 500ug | EUR 663 |
![]() Recombinant HSV HSV-2 gD Protein, His, E.coli-100ug |
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QP12344-100ug | EnQuireBio | 100ug | EUR 218 |
![]() Recombinant HSV HSV-2 gD Protein, His, E.coli-1mg |
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QP12344-1mg | EnQuireBio | 1mg | EUR 1261 |
![]() Recombinant HSV HSV-2 gD Protein, His, E.coli-500ug |
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QP12344-500ug | EnQuireBio | 500ug | EUR 663 |
![]() Recombinant HSV HSV-2 gG Protein, Untagged, E.coli-100ug |
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QP12346-100ug | EnQuireBio | 100ug | EUR 218 |
![]() Recombinant HSV HSV-2 gG Protein, Untagged, E.coli-1mg |
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QP12346-1mg | EnQuireBio | 1mg | EUR 1061 |
![]() Recombinant HSV HSV-2 gG Protein, Untagged, E.coli-500ug |
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QP12346-500ug | EnQuireBio | 500ug | EUR 663 |
![]() Recombinant HSV HSV-2 VP22 Protein, His, E.coli-100ug |
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QP12348-100ug | EnQuireBio | 100ug | EUR 218 |
![]() Recombinant HSV HSV-2 VP22 Protein, His, E.coli-1mg |
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QP12348-1mg | EnQuireBio | 1mg | EUR 1261 |
![]() Recombinant HSV HSV-2 VP22 Protein, His, E.coli-500ug |
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QP12348-500ug | EnQuireBio | 500ug | EUR 663 |
![]() CaspSELECT Caspase 3 Immunoassay Kit |
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55R-1338 | Fitzgerald | 100 assays | EUR 1022 |
Description: Assay Kit for detection of Capase 3 activity in the research laboratory |
![]() cAMP Direct Immunoassay Kit (Colorimetric) |
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K371-100 | Biovision | EUR 512 |
![]() cGMP Direct Immunoassay Kit (Colorimetric) |
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K372-100 | Biovision | EUR 512 |
A Perspective on Enzyme Inhibitors from Marine Organisms
Marine habitats are promising sources for the identification of novel organisms in addition to pure merchandise. Nonetheless, we lack detailed data on a lot of the marine biosphere. Within the final decade, quite a lot of experiences described the potential of figuring out novel bioactive compounds or secondary metabolites from marine environments.
That is, and might be, a promising supply for candidate compounds in pharma analysis and chemical biology. Lately, a variety of novel methods had been launched into the sphere, and it has turn out to be simpler to truly prospect for pure merchandise, equivalent to enzyme inhibitors. These novel compounds then must be characterised and evaluated compared to well-known representatives.
A variety of present analysis tasks goal the exploitation of marine organisms and thus the corresponding range of metabolites. These are sometimes encountered as potential medicine or organic energetic compounds. Amongst these, the category of enzyme inhibitors is a crucial group of compounds. There’s room for brand spanking new discoveries, and a few more moderen discoveries are highlighted herein.
World evaluation of adenylate-forming enzymes reveals β-lactone biosynthesis pathway in pathogenic Nocardia
Enzymes that cleave ATP to activate carboxylic acids play important roles in major and secondary metabolism in all domains of life. Class I adenylate-forming enzymes share a conserved structural fold however act on a variety of substrates to catalyze reactions concerned in bioluminescence, nonribosomal peptide biosynthesis, fatty acid activation, and β-lactone formation.
Regardless of their metabolic significance, the substrates and features of the overwhelming majority of adenylate-forming enzymes are unknown with out instruments out there to precisely predict them. Given the essential roles of adenylate-forming enzymes in biosynthesis, this additionally severely limits our capacity to foretell pure product buildings from biosynthetic gene clusters.
Right here we used machine studying to foretell adenylate-forming enzyme operate and substrate specificity from protein sequences. We constructed a web-based predictive instrument and used it to comprehensively map the biochemical range of adenylate-forming enzymes throughout >50,000 candidate biosynthetic gene clusters in bacterial, fungal, and plant genomes.
Ancestral phylogenetic reconstruction and sequence similarity networking of enzymes from these clusters prompt divergent evolution of the adenylate-forming superfamily from a core enzyme scaffold most associated to modern CoA ligases in direction of extra specialised features together with β-lactone synthetases.
Our classifier predicted β-lactone synthetases in uncharacterized biosynthetic gene clusters conserved in >90 completely different strains of Nocardia To check our prediction, we purified a candidate β-lactone synthetase from Nocardia brasiliensis and reconstituted the biosynthetic pathway in vitro to hyperlink the gene cluster to the β-lactone pure product, nocardiolactone. We anticipate our machine studying method will support in practical classification of enzymes and advance pure product discovery.
![]() Co 102862 |
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B7135-10 | ApexBio | 10 mg | EUR 276 |
![]() Co 102862 |
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B7135-50 | ApexBio | 50 mg | EUR 999 |
![]() Individual Reaction Mix 4 |
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G065-4 | ABM | 200 reactions | EUR 167 |
![]() Colorectal Cancer Exosome |
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P141-CO | 101Bio | - | Ask for price |
![]() Colorectal Cancer Exosome RNA |
|||
P241-CO | 101Bio | - | Ask for price |
![]() Human Lactate Dehydrogenase 4 Enzyme |
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abx070017-100Units | Abbexa | 100 Units | EUR 1191 |
![]() DNA Polymerase Enzyme (4 kb) |
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abx071004-10kU | Abbexa | 10 kU | EUR 384 |
![]() DNA Polymerase Enzyme (4 kb) |
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abx071004-3kU | Abbexa | 3 kU | EUR 230 |
![]() DNA Polymerase Enzyme (4 kb) |
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abx071004-500U | Abbexa | 500 U | EUR 175 |
![]() DNA Polymerase Enzyme (4 kb) |
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abx071004-50kU | Abbexa | 50 kU | EUR 1052 |
![]() pBbA5c-MevT(CO)-T1-MBIS(CO, ispA) |
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PVT17450 | Lifescience Market | 2 ug | EUR 300 |
![]() pLenti-CLDN1 shRNA-4 Plasmid |
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PVTBAV04867-4 | Lifescience Market | 2 ug | EUR 356 |
![]() Feline IL-4 Recombinant Protein |
|||
R00230-4 | BosterBio | 5ug/vial | EUR 259 |
Description: IL-4 has many biological roles, including the stimulation of activated B-cell and T-cell proliferation, and the differentiation of CD4+ T-cells into Th2 cells. It is a key regulator in humoral and adaptive immunity. Feline IL-4 Recombinant Protein is purified interleukin-4 produced in yeast. |
![]() Recombinant Human sTNF Receptor Type II Protein |
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PROTP20333-4 | BosterBio | 20ug | EUR 317 |
Description: TNFRII is a member of the TNFR family of transmembrane proteins, and is expressed in immune cells and certain endothelial cells. It is a high affinity receptor for TNF-α but manifests a lower affinity to TNF-β. Signaling through this receptor regulates various biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, coagulation, and neurotransmission. Soluble TNFRII is capable of inhibiting TNF-α induced activities by acting as a decoy receptor. Recombinant human sTNFRII is an 18.9 kDa protein (174 amino acid residues) comprising the cysteine rich ligand binding portion of the extracellular domain of the TNFRII protein. |
![]() Recombinant Human PF-4 (CXCL4) Protein |
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PROTP02776-4 | BosterBio | 20ug | EUR 317 |
Description: PF-4 is a CXC chemokine that is expressed in megakaryocytes and stored in the α-granules of platelets. PF-4 is chemotactic towards neutrophils and monocytes and has been shown to inhibit angiogenesis. Recombinant human PF-4 is a 7.8 kDa protein containing 70 amino acid residues, including the four highly conserved residues present in CXC chemokines. |
![]() Mouse FibrOut 4, for brain, neural |
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4-20507 | CHI Scientific | 1 ml | Ask for price |
![]() Mouse FibrOut 4, for brain, neural |
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4-20508 | CHI Scientific | 5 x 1 ml | Ask for price |
![]() Rat FibrOut 4, for brain, neural |
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4-20533 | CHI Scientific | 1 ml | Ask for price |
![]() Rat FibrOut 4, for brain, neural |
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4-20534 | CHI Scientific | 5 x 1 ml | Ask for price |
![]() Human FibrOut 4, for brain, neural |
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4-21552 | CHI Scientific | 1 ml | Ask for price |
![]() Human FibrOut 4, for brain, neural |
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4-21553 | CHI Scientific | 5 x 1 ml | Ask for price |
![]() DIGITAL SHAKER FOR 4 MICROPLATES, 120V |
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6780-4 | CORNING | 1/pk | EUR 798 |
Description: Lab Equipment; Shakers & Mixers |
![]() Recombinant Human 4-1BB Receptor Protein |
|||
PROTQ07011-4 | BosterBio | 20ug | EUR 317 |
Description: 4-1BB Receptor, a member of the TNF superfamily of receptors, is mainly expressed on the surface of a variety of T cells, but also found in B cells, monocytes, and various transformed cell lines. 4-1BB Receptor binds to 4-1BBL to provide a co-stimulatory signal for T lymphocytes. Signaling by 4-1BB Receptor has been implicated in the antigen-presentation process and generation of cytotoxic T cells. The human 4-1BB Receptor gene codes for a 255 amino acid type I transmembrane protein containing a 17 amino acid N-terminal signal sequence, a 169 amino acid extracellular domain, a 27 amino acid transmembrane domain and a 42 amino acid cytoplasmic domain. Recombinant human soluble 4-1BB Receptor is a 167 amino acid polypeptide (17.7 kDa), which contains the cysteine rich TNFR-like extracellular domain of 4-1BB Receptor. |
![]() Frit Kit |
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FRIT-KIT | Next Advance | 1each | EUR 124 |
Description: Kit to create frits in capillaries. Includes formamide, Kasil-1, Kasil-1624 and a cleaving tool. |
![]() Recombinant Human Tumor Necrosis Factor Receptor Type 4 |
|||
CC136-101 | GenDepot | 1mg | EUR 10310 |
![]() Column Packing Kit |
|||
PACK-KIT | Next Advance | 1pack | EUR 1035 |
Description: Column packing kit for pressure cells. Includes: HPREG regulator, TBNG10 tubing, CAP-75 capillary, and STRB5X2 stir bar. |
![]() Lung Dissociation System 8 (Alveolar type II), Rat |
|||
4-20318 | CHI Scientific | ea | Ask for price |
![]() CO-1686 (Rociletinib) |
|||
2794-25 | Biovision | EUR 675 |
![]() CO-1686 (Rociletinib) |
|||
2794-5 | Biovision | EUR 207 |
![]() Co-Precipitant, Pink |
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BIO-37075 | Bioline | 1.5ml, 5mg/ml | Ask for price |
![]() Co 101244 hydrochloride |
|||
B7062-10 | ApexBio | 10 mg | EUR 334 |
![]() Co 101244 hydrochloride |
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B7062-50 | ApexBio | 50 mg | EUR 1243 |
![]() Bone Dissociation System 4 (Osteoblasts), Adult Mouse |
|||
4-20214 | CHI Scientific | ea | Ask for price |
![]() Liver Dissociation System 4 (Hepatocytes, rat), Rat |
|||
4-20304 | CHI Scientific | ea | Ask for price |
![]() Pituitary Dissociation System 4 (Pituitary), Adult mouse |
|||
4-20404 | CHI Scientific | ea | Ask for price |
![]() Thymus Dissociation System 4 (Epithelial), Adult rat |
|||
4-20444 | CHI Scientific | ea | Ask for price |
![]() StemBoost? Growth Factor Set V |
|||
K881-4 | Biovision | EUR 697 |
![]() StemBoost? Growth Factor Set VII |
|||
K883-4 | Biovision | EUR 697 |
![]() PCR Mycoplasma Detection Kit |
|||
M034-Kit | TOKU-E | Kit | EUR 266 |
![]() Cartilage Dissociation System 4 (Chondrocytes), Mouse and Rat |
|||
4-20234 | CHI Scientific | ea | Ask for price |
![]() Mammary Dissociation System 4 (Epithelial, Swiss 3T3), Mouse |
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4-20324 | CHI Scientific | ea | Ask for price |
![]() Pancreas Dissociation System 4 (Islets), Mouse and Rat |
|||
4-20374 | CHI Scientific | ea | Ask for price |
![]() Skin Dissociation System 4 (Keratinocytes), Mouse and Rat |
|||
4-20434 | CHI Scientific | ea | Ask for price |
![]() DIGITAL SHAKER FOR 4 MICROPLATES, 230V-EU PLUG |
|||
6781-4 | CORNING | 1/pk | EUR 798 |
Description: Lab Equipment; Shakers & Mixers |
![]() DIGITAL SHAKER FOR 4 MICROPLATES, 230V-UK PLUG |
|||
6782-4 | CORNING | 1/pk | EUR 798 |
Description: Lab Equipment; Shakers & Mixers |
![]() Human Peroxisomal Multifunctional Enzyme Type 2 (HSD17B4) ELISA Kit |
|||
abx387893-96tests | Abbexa | 96 tests | EUR 911 |
![]() Lung Dissociation System 8 (Alveolar type I), Mouse and Rat |
|||
4-20315 | CHI Scientific | ea | Ask for price |
![]() Lung Dissociation System 6 (Fibroblasts & Type II), Mouse and Rat |
|||
4-20316 | CHI Scientific | ea | Ask for price |
![]() Lung Dissociation System 7 (Alveolar type II, Alveolar epithelial), Mouse |
|||
4-20317 | CHI Scientific | ea | Ask for price |
![]() Human Carbohydrate Antigen 72-4 (CA72-4) ELISA Kit |
|||
DLR-CA72-4-Hu-48T | DL Develop | 48T | EUR 479 |
Description: A sandwich quantitative ELISA assay kit for detection of Human Carbohydrate Antigen 72-4 (CA72-4) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
![]() Human Carbohydrate Antigen 72-4 (CA72-4) ELISA Kit |
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DLR-CA72-4-Hu-96T | DL Develop | 96T | EUR 621 |
Description: A sandwich quantitative ELISA assay kit for detection of Human Carbohydrate Antigen 72-4 (CA72-4) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
![]() Human Carbohydrate Antigen 72-4 (CA72-4) ELISA Kit |
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RD-CA72-4-Hu-48Tests | Reddot Biotech | 48 Tests | EUR 478 |
![]() Human Carbohydrate Antigen 72-4 (CA72-4) ELISA Kit |
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RD-CA72-4-Hu-96Tests | Reddot Biotech | 96 Tests | EUR 662 |
![]() Human Carbohydrate Antigen 72-4 (CA72-4) ELISA Kit |
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RDR-CA72-4-Hu-48Tests | Reddot Biotech | 48 Tests | EUR 500 |
![]() Human Carbohydrate Antigen 72-4 (CA72-4) ELISA Kit |
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RDR-CA72-4-Hu-96Tests | Reddot Biotech | 96 Tests | EUR 692 |
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4-20194 | CHI Scientific | ea | Ask for price |
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4-20224 | CHI Scientific | ea | Ask for price |
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4-20244 | CHI Scientific | ea | Ask for price |
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4-20274 | CHI Scientific | ea | Ask for price |
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4-20334 | CHI Scientific | ea | Ask for price |
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4-20394 | CHI Scientific | ea | Ask for price |
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CAS400A-KIT | SBI | 1 kit (10 rxn) | EUR 1110 |
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1-CSB-YP010774HU | Cusabio |
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Description: Recombinant Human Peroxisomal multifunctional enzyme type 2(HSD17B4) expressed in Yeast |
![]() Peroxisomal Multifunctional Enzyme Type 2 (HSD17B4) Antibody |
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20-abx121133 | Abbexa |
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![]() Peroxisomal Multifunctional Enzyme Type 2 (HSD17B4) Antibody |
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20-abx113089 | Abbexa |
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![]() Peroxisomal Multifunctional Enzyme Type 2 (HSD17B4) Antibody |
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20-abx004727 | Abbexa |
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![]() Peroxisomal Multifunctional Enzyme Type 2 (HSD17B4) Antibody |
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abx026859-400ul | Abbexa | 400 ul | EUR 523 |
![]() Peroxisomal Multifunctional Enzyme Type 2 (HSD17B4) Antibody |
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abx026859-80l | Abbexa | 80 µl | EUR 286 |
![]() Peroxisomal Multifunctional Enzyme Type 2 (HSD17B4) Antibody |
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20-abx320221 | Abbexa |
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![]() Peroxisomal Multifunctional Enzyme Type 2 (HSD17B4) Antibody |
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20-abx322147 | Abbexa |
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![]() Peroxisomal Multifunctional Enzyme Type 2 (HSD17B4) Antibody |
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abx216048-100ug | Abbexa | 100 ug | EUR 439 |
![]() Peroxisomal Multifunctional Enzyme Type 2 (HSD17B4) Antibody |
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20-abx242132 | Abbexa |
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![]() Peroxisomal Multifunctional Enzyme Type 2 (HSD17B4) Antibody |
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20-abx242133 | Abbexa |
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![]() Peroxisomal Multifunctional Enzyme Type 2 (HSD17B4) Antibody |
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abx234026-100ug | Abbexa | 100 ug | EUR 481 |
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20-abx327690 | Abbexa |
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PCR-H524-48R | Bioingentech | 50T | EUR 823 |
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PCR-H524-96R | Bioingentech | 100T | EUR 1113 |
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CASLV100PA-KIT | SBI | 1 Kit | EUR 1132 |
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CASLV105PA-KIT | SBI | 1 Kit | EUR 1132 |
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CASLV120PA-KIT | SBI | 1 Kit | EUR 1132 |
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CASLV125PA-KIT | SBI | 1 Kit | EUR 1132 |
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M1040-4 | Biovision | EUR 909 |
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M1041-4 | Biovision | EUR 1137 |
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M1042-4 | Biovision | EUR 909 |