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Catalytic Cycle of the Antioxidant and Cancer-Associated Human NQO1 Enzyme

The Catalytic Cycle of the Antioxidant and Most cancers-Related Human NQO1 Enzyme: Hydride Switch, Conformational Dynamics and Useful Cooperativity
Human NQO1 [NAD(H):quinone oxidoreductase 1] is a multi-functional and stress-inducible dimeric protein concerned within the antioxidant protection, the activation of most cancers prodrugs and the stabilization of oncosuppressors. Regardless of its roles in human ailments, corresponding to most cancers and neurological issues, an in depth characterization of its enzymatic cycle remains to be missing.
On this work, we offer a complete evaluation of the NQO1 catalytic cycle utilizing fast mixing strategies, together with multiwavelength and spectral deconvolution research, kinetic modeling and temperature-dependent kinetic isotope results (KIEs).
Our outcomes systematically assist the existence of two pathways for hydride transfer all through the NQO1 catalytic cycle, possible reflecting that the 2 energetic websites within the dimer catalyze two-electron discount with completely different charges, according to the cooperative binding of inhibitors corresponding to dicoumarol.
This unfavorable cooperativity in NQO1 redox exercise represents a form of half-of-sites exercise. Evaluation of OkayIEs and their temperature dependence additionally present considerably completely different contributions from quantum tunneling, structural dynamics and reorganizations to catalysis on the two energetic websites.
Our work will enhance our understanding of the consequences of cancer-associated single amino acid variants and post-translational modifications on this protein of excessive relevance in most cancers development and remedy.

Creatine Kinase Isoenzyme MB Assay Kit |
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abx098421-Hitachi7170R160ml1R215ml1 | Abbexa | Hitachi 7170; R1: 60ml×1 R2: 15ml×1 | EUR 331 |
Rat Creatine Kinase MB isoenzyme(CK-MB)ELISA Kit |
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GA-E0319RT-48T | GenAsia Biotech | 48T | EUR 317 |
Rat Creatine Kinase MB isoenzyme(CK-MB)ELISA Kit |
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GA-E0319RT-96T | GenAsia Biotech | 96T | EUR 496 |
Mouse Creatine Kinase MB isoenzyme(CK-MB)ELISA Kit |
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GA-E0320MS-48T | GenAsia Biotech | 48T | EUR 336 |
Mouse Creatine Kinase MB isoenzyme(CK-MB)ELISA Kit |
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GA-E0320MS-96T | GenAsia Biotech | 96T | EUR 534 |
Human Creatine Kinase MB isoenzyme(CK-MB)ELISA Kit |
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GA-E0955HM-48T | GenAsia Biotech | 48T | EUR 289 |
Human Creatine Kinase MB isoenzyme(CK-MB)ELISA Kit |
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GA-E0955HM-96T | GenAsia Biotech | 96T | EUR 466 |
Human Creatine Kinase MB isoenzyme,CK-MB ELISA Kit |
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201-12-0939 | SunredBio | 96 tests | EUR 440 |
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids. |
Mouse Creatine Kinase MB Isoenzyme (CK-MB) CLIA Kit |
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abx195424-96tests | Abbexa | 96 tests | EUR 825 |
Rat Creatine Kinase MB Isoenzyme (CK-MB) CLIA Kit |
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abx195425-96tests | Abbexa | 96 tests | EUR 825 |
Rat CK-MB(Creatine Kinase MB Isoenzyme) ELISA Kit |
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STJ150415 | St John's Laboratory | 1 kit | EUR 412 |
Description: The kit is a sandwich enzyme immunoassay for in vitro quantitative measurement of CK-MB in Rat serum, plasma and other biological fluids |
Mouse CK-MB(Creatine Kinase MB Isoenzyme) ELISA Kit |
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EM0929 | FN Test | 96T | EUR 524.1 |
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Mus ;Sensitivity: 46.875pg/ml |
Rat CK-MB(Creatine Kinase MB Isoenzyme) ELISA Kit |
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ER0841 | FN Test | 96T | EUR 524.1 |
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Rattus;Sensitivity: 18.75pg/ml |
Pig creatine kinase MB isoenzyme (CK-MB) ELISA kit |
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CSB-EQ027653PI-24T | Cusabio | 1 plate of 24 wells | EUR 165 |
Description: Quantitativesandwich ELISA kit for measuring Pig creatine kinase MB isoenzyme (CK-MB) in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price. |
Pig creatine kinase MB isoenzyme (CK-MB) ELISA kit |
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1-CSB-EQ027653PI | Cusabio |
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Description: Quantitativesandwich ELISA kit for measuring Pig creatine kinase MB isoenzyme (CK-MB) in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits. |
Rabbit creatine kinase MB isoenzyme (CK-MB) ELISA kit |
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CSB-EQ027653RB-24T | Cusabio | 1 plate of 24 wells | EUR 165 |
Description: Quantitativesandwich ELISA kit for measuring Rabbit creatine kinase MB isoenzyme (CK-MB) in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price. |
Rabbit creatine kinase MB isoenzyme (CK-MB) ELISA kit |
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1-CSB-EQ027653RB | Cusabio |
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Description: Quantitativesandwich ELISA kit for measuring Rabbit creatine kinase MB isoenzyme (CK-MB) in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits. |
Human Creatine Kinase MB isoenzyme, CK-MB ELISA Kit |
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CSB-E05140h-24T | Cusabio | 1 plate of 24 wells | EUR 165 |
Description: Quantitativesandwich ELISA kit for measuring Human Creatine Kinase MB isoenzyme, CK-MB in samples from serum, plasma, urine, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price. |
Human Creatine Kinase MB isoenzyme, CK-MB ELISA Kit |
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1-CSB-E05140h | Cusabio |
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Description: Quantitativesandwich ELISA kit for measuring Human Creatine Kinase MB isoenzyme, CK-MB in samples from serum, plasma, urine, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits. |
Rat Creatine Kinase MB isoenzyme, CK-MB ELISA Kit |
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CSB-E14403r-24T | Cusabio | 1 plate of 24 wells | EUR 165 |
Description: Quantitativesandwich ELISA kit for measuring Rat Creatine Kinase MB isoenzyme, CK-MB in samples from serum, urine, tissue homogenates, plasma. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price. |
Rat Creatine Kinase MB isoenzyme, CK-MB ELISA Kit |
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1-CSB-E14403r | Cusabio |
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Description: Quantitativesandwich ELISA kit for measuring Rat Creatine Kinase MB isoenzyme, CK-MB in samples from serum, urine, tissue homogenates, plasma. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits. |
Mouse Creatine Kinase MB isoenzyme, CK-MB ELISA Kit |
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CSB-E14404m-24T | Cusabio | 1 plate of 24 wells | EUR 165 |
Description: Quantitativesandwich ELISA kit for measuring Mouse Creatine Kinase MB isoenzyme, CK-MB in samples from serum, plasma, cell culture supernates, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price. |
Mouse Creatine Kinase MB isoenzyme, CK-MB ELISA Kit |
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1-CSB-E14404m | Cusabio |
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Description: Quantitativesandwich ELISA kit for measuring Mouse Creatine Kinase MB isoenzyme, CK-MB in samples from serum, plasma, cell culture supernates, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits. |
Canine Creatine Kinase MB isoenzyme (CK-MB)ELISA Kit |
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CSB-E15852c-24T | Cusabio | 1 plate of 24 wells | EUR 165 |
Description: Quantitativecompetitive ELISA kit for measuring Canine Creatine Kinase MB isoenzyme (CK-MB) in samples from serum, plasma. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price. |
Canine Creatine Kinase MB isoenzyme (CK-MB)ELISA Kit |
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1-CSB-E15852c | Cusabio |
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Description: Quantitativecompetitive ELISA kit for measuring Canine Creatine Kinase MB isoenzyme (CK-MB) in samples from serum, plasma. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits. |
Rat Creatine Kinase MB isoenzyme(CK-MB)ELISA Kit |
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QY-E11333 | Qayee Biotechnology | 96T | EUR 361 |
Mouse Creatine Kinase MB isoenzyme(CK-MB)ELISA Kit |
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QY-E20398 | Qayee Biotechnology | 96T | EUR 361 |
Human Creatine Kinase MB isoenzyme(CK-MB)ELISA Kit |
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QY-E03021 | Qayee Biotechnology | 96T | EUR 361 |
Human Creatine Kinase MB isoenzyme,CK-MB ELISA Kit |
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CN-04036H1 | ChemNorm | 96T | EUR 461 |
Human Creatine Kinase MB isoenzyme,CK-MB ELISA Kit |
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CN-04036H2 | ChemNorm | 48T | EUR 310 |
Creatine kinase isoenzyme(CK-MB) Antigen(Crude) |
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E64C00701 | EnoGene | 100ug | EUR 1350 |
Mouse Creatine Kinase MB isoenzyme ELISA Kit |
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ELA-E0479m | Lifescience Market | 96 Tests | EUR 865 |
Mouse Creatine Kinase MB isoenzyme ELISA kit |
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E03C0085-192T | BlueGene | 192 tests | EUR 1270 |
Description: A competitive ELISA for quantitative measurement of Mouse Creatine Kinase MB isoenzyme in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Mouse Creatine Kinase MB isoenzyme ELISA kit |
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E03C0085-48 | BlueGene | 1 plate of 48 wells | EUR 520 |
Description: A competitive ELISA for quantitative measurement of Mouse Creatine Kinase MB isoenzyme in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Mouse Creatine Kinase MB isoenzyme ELISA kit |
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E03C0085-96 | BlueGene | 1 plate of 96 wells | EUR 685 |
Description: A competitive ELISA for quantitative measurement of Mouse Creatine Kinase MB isoenzyme in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Dog Creatine Kinase MB isoenzyme ELISA kit |
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E08C0085-192T | BlueGene | 192 tests | EUR 1270 |
Description: A competitive ELISA for quantitative measurement of Canine Creatine Kinase MB isoenzyme in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Dog Creatine Kinase MB isoenzyme ELISA kit |
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E08C0085-48 | BlueGene | 1 plate of 48 wells | EUR 520 |
Description: A competitive ELISA for quantitative measurement of Canine Creatine Kinase MB isoenzyme in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Dog Creatine Kinase MB isoenzyme ELISA kit |
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E08C0085-96 | BlueGene | 1 plate of 96 wells | EUR 685 |
Description: A competitive ELISA for quantitative measurement of Canine Creatine Kinase MB isoenzyme in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rat Creatine Kinase MB isoenzyme ELISA kit |
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E02C0085-192T | BlueGene | 192 tests | EUR 1270 |
Description: A competitive ELISA for quantitative measurement of Rat Creatine Kinase MB isoenzyme in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rat Creatine Kinase MB isoenzyme ELISA kit |
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E02C0085-48 | BlueGene | 1 plate of 48 wells | EUR 520 |
Description: A competitive ELISA for quantitative measurement of Rat Creatine Kinase MB isoenzyme in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rat Creatine Kinase MB isoenzyme ELISA kit |
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E02C0085-96 | BlueGene | 1 plate of 96 wells | EUR 685 |
Description: A competitive ELISA for quantitative measurement of Rat Creatine Kinase MB isoenzyme in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rabbit Creatine Kinase MB isoenzyme ELISA kit |
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E04C0085-192T | BlueGene | 192 tests | EUR 1270 |
Description: A competitive ELISA for quantitative measurement of Rabbit Creatine Kinase MB isoenzyme in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rabbit Creatine Kinase MB isoenzyme ELISA kit |
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E04C0085-48 | BlueGene | 1 plate of 48 wells | EUR 520 |
Description: A competitive ELISA for quantitative measurement of Rabbit Creatine Kinase MB isoenzyme in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rabbit Creatine Kinase MB isoenzyme ELISA kit |
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E04C0085-96 | BlueGene | 1 plate of 96 wells | EUR 685 |
Description: A competitive ELISA for quantitative measurement of Rabbit Creatine Kinase MB isoenzyme in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Pig Creatine Kinase MB isoenzyme ELISA kit |
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E07C0085-192T | BlueGene | 192 tests | EUR 1270 |
Description: A competitive ELISA for quantitative measurement of Porcine Creatine Kinase MB isoenzyme in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Pig Creatine Kinase MB isoenzyme ELISA kit |
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E07C0085-48 | BlueGene | 1 plate of 48 wells | EUR 520 |
Description: A competitive ELISA for quantitative measurement of Porcine Creatine Kinase MB isoenzyme in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Pig Creatine Kinase MB isoenzyme ELISA kit |
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E07C0085-96 | BlueGene | 1 plate of 96 wells | EUR 685 |
Description: A competitive ELISA for quantitative measurement of Porcine Creatine Kinase MB isoenzyme in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Goat Creatine Kinase MB isoenzyme ELISA kit |
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E06C0085-192T | BlueGene | 192 tests | EUR 1270 |
Description: A competitive ELISA for quantitative measurement of Goat Creatine Kinase MB isoenzyme in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Goat Creatine Kinase MB isoenzyme ELISA kit |
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E06C0085-48 | BlueGene | 1 plate of 48 wells | EUR 520 |
Description: A competitive ELISA for quantitative measurement of Goat Creatine Kinase MB isoenzyme in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Goat Creatine Kinase MB isoenzyme ELISA kit |
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E06C0085-96 | BlueGene | 1 plate of 96 wells | EUR 685 |
Description: A competitive ELISA for quantitative measurement of Goat Creatine Kinase MB isoenzyme in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Human Creatine Kinase MB isoenzyme ELISA kit |
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E01C0085-192T | BlueGene | 192 tests | EUR 1270 |
Description: A competitive ELISA for quantitative measurement of Human Creatine Kinase MB isoenzyme in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Human Creatine Kinase MB isoenzyme ELISA kit |
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E01C0085-48 | BlueGene | 1 plate of 48 wells | EUR 520 |
Description: A competitive ELISA for quantitative measurement of Human Creatine Kinase MB isoenzyme in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Human Creatine Kinase MB isoenzyme ELISA kit |
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E01C0085-96 | BlueGene | 1 plate of 96 wells | EUR 685 |
Description: A competitive ELISA for quantitative measurement of Human Creatine Kinase MB isoenzyme in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Monkey Creatine Kinase MB isoenzyme ELISA kit |
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E09C0085-192T | BlueGene | 192 tests | EUR 1270 |
Description: A competitive ELISA for quantitative measurement of Monkey Creatine Kinase MB isoenzyme in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Monkey Creatine Kinase MB isoenzyme ELISA kit |
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E09C0085-48 | BlueGene | 1 plate of 48 wells | EUR 520 |
Description: A competitive ELISA for quantitative measurement of Monkey Creatine Kinase MB isoenzyme in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Monkey Creatine Kinase MB isoenzyme ELISA kit |
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E09C0085-96 | BlueGene | 1 plate of 96 wells | EUR 685 |
Description: A competitive ELISA for quantitative measurement of Monkey Creatine Kinase MB isoenzyme in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
CLIA kit for Mouse CK-MB (Creatine Kinase MB Isoenzyme) |
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E-CL-M0228 | Elabscience Biotech | 1 plate of 96 wells | EUR 584 |
Description: A sandwich CLIA kit for quantitative measurement of Mouse CK-MB (Creatine Kinase MB Isoenzyme) in samples from Serum, Plasma, Cell supernatant |
CLIA kit for Rat CK-MB (Creatine Kinase MB Isoenzyme) |
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E-CL-R0722 | Elabscience Biotech | 1 plate of 96 wells | EUR 584 |
Description: A sandwich CLIA kit for quantitative measurement of Rat CK-MB (Creatine Kinase MB Isoenzyme) in samples from Serum, Plasma, Cell supernatant |
ELISA kit for Rat Creatine Kinase MB isoenzyme (CK-MB) |
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KTE101041-48T | Abbkine | 48T | EUR 354 |
Description: Quantitative sandwich ELISA for measuring Rat Creatine Kinase MB isoenzyme (CK-MB) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. |
ELISA kit for Rat Creatine Kinase MB isoenzyme (CK-MB) |
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KTE101041-5platesof96wells | Abbkine | 5 plates of 96 wells | EUR 2252 |
Description: Quantitative sandwich ELISA for measuring Rat Creatine Kinase MB isoenzyme (CK-MB) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. |
ELISA kit for Rat Creatine Kinase MB isoenzyme (CK-MB) |
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KTE101041-96T | Abbkine | 96T | EUR 572 |
Description: Quantitative sandwich ELISA for measuring Rat Creatine Kinase MB isoenzyme (CK-MB) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. |
Mouse Creatine Kinase MB Isoenzyme (CKMB) ELISA Kit |
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20-abx153828 | Abbexa |
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Human Creatine Kinase MB Isoenzyme (CKMB) ELISA Kit |
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abx050249-96tests | Abbexa | 96 tests | EUR 637 |
Creatine Kinase MB Isoenzyme Type-1 Protein (Recombinant) |
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20-abx073921 | Abbexa |
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Creatine Kinase MB Isoenzyme Type-2 Protein (Recombinant) |
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20-abx073949 | Abbexa |
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Recombinant Human Creatine Kinase MB Isoenzyme Type-1 |
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7-04240 | CHI Scientific | 10µg | Ask for price |
Recombinant Human Creatine Kinase MB Isoenzyme Type-1 |
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7-04241 | CHI Scientific | 50µg | Ask for price |
Recombinant Human Creatine Kinase MB Isoenzyme Type-1 |
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7-04242 | CHI Scientific | 1mg | Ask for price |
Recombinant Human Creatine Kinase MB Isoenzyme Type-2 |
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7-04243 | CHI Scientific | 10µg | Ask for price |
Recombinant Human Creatine Kinase MB Isoenzyme Type-2 |
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7-04244 | CHI Scientific | 50µg | Ask for price |
Recombinant Human Creatine Kinase MB Isoenzyme Type-2 |
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7-04245 | CHI Scientific | 1mg | Ask for price |
Human Creatine Kinase MB Isoenzyme (CKMB) CLIA Kit |
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20-abx491540 | Abbexa |
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Mouse Creatine Kinase MB Isoenzyme (CKMB) CLIA Kit |
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20-abx491541 | Abbexa |
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Rat Creatine Kinase MB Isoenzyme (CKMB) CLIA Kit |
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20-abx491542 | Abbexa |
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Pig Creatine Kinase MB Isoenzyme (CKMB) ELISA Kit |
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abx255449-96tests | Abbexa | 96 tests | EUR 786 |
Rat Creatine Kinase MB Isoenzyme (CKMB) ELISA Kit |
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abx256809-96tests | Abbexa | 96 tests | EUR 754 |
Rabbit Creatine Kinase MB Isoenzyme (CKMB) ELISA Kit |
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abx256993-96tests | Abbexa | 96 tests | EUR 786 |
Human Creatine Kinase MB Isoenzyme (CKMB) ELISA Kit |
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abx252900-96tests | Abbexa | 96 tests | EUR 668 |
Mouse Creatine Kinase MB Isoenzyme (CKMB) ELISA Kit |
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abx255269-96tests | Abbexa | 96 tests | EUR 707 |
Sheep Creatine Kinase MB Isoenzyme (CKMB) ELISA Kit |
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abx364238-96tests | Abbexa | 96 tests | EUR 926 |
Chicken Creatine Kinase MB Isoenzyme (CKMB) ELISA Kit |
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abx355524-96tests | Abbexa | 96 tests | EUR 825 |
Rat Creatine Kinase MB Isoenzyme (CKMB) ELISA Kit |
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20-abx155346 | Abbexa |
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Ubiquitin-Conjugating Enzyme E2 E Inhibits the Accumulation of Rice Stripe Virus in Laodelphax striatellus (Fallén)
The ubiquitin-proteasome system (UPS) is a necessary protagonist in host-pathogen interactions. Among the many three lessons of enzymes within the UPS, ubiquitin-conjugating enzyme E2 performs a twin position in viral pathogenesis; nevertheless, the position of insect E2s in interactions with plant viruses is unclear.
Twenty E2-encoding genes in Laodelphax striatellus, the small brown planthopper, have been recognized and categorized into 17 teams by transcriptomic and phylogenetic evaluation.
Full-length cDNAs of 4 LstrE2s (LstrE2 A/E/G2/H) have been obtained by rapid-amplification of cDNA ends (RACE-PCR) evaluation.
Expression of the 4 LstrE2s confirmed tissue- and development-specific patterns. RT-qPCR analyses revealed that Rice stripe viruse (RSV) an infection elevated the extent of LstrE2 A/E/G2/H.
Additional research indicated that repression of LstrE2 E by way of RNAi brought on important will increase within the expression of RSV coat protein mRNA and protein ranges.
These findings counsel that LstrE2 E inhibits RSV accumulation within the planthopper physique. Understanding the perform of LstrE2 E in RSV accumulation might in the end consequence within the growth of novel antiviral methods.
Pyridoxal 5′-Phosphate-Dependent Enzymes on the Crossroads of Host-Microbe Tryptophan Metabolism
The chemical processes going down in people intersects the myriad of metabolic pathways occurring in commensal microorganisms that colonize the physique to generate a posh biochemical community that regulates a number of features of human life.
The position of tryptophan (Trp) metabolism on the intersection between the host and microbes is more and more being acknowledged, and a number of pathways of Trp utilization in both route have been recognized with the manufacturing of a variety of bioactive merchandise.
It comes {that a} dysregulation of Trp metabolism in both the host or the microbes might unbalance the manufacturing of metabolites with potential pathological penalties.
The flexibility to redirect the Trp flux to revive a homeostatic manufacturing of Trp metabolites might characterize a sound therapeutic technique for a wide range of pathological situations, however figuring out metabolic checkpoints that might be exploited to govern the Trp metabolic community remains to be an unmet want.
On this overview, we put ahead the speculation that pyridoxal 5′-phosphate (PLP)-dependent enzymes, which regulate a number of pathways of Trp metabolism in each the host and in microbes, may characterize crucial nodes and that modulating the degrees of vitamin B6, from which PLP is derived, may characterize a metabolic checkpoint to re-orienteer Trp flux for therapeutic functions.
Recombinant Angiotensin I Converting Enzyme (ACE) |
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4-RPA004Hu02 | Cloud-Clone |
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Description: Recombinant Human Angiotensin I Converting Enzyme expressed in: E.coli |
Recombinant Angiotensin I Converting Enzyme (ACE) |
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4-RPA004Mu01 | Cloud-Clone |
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Description: Recombinant Mouse Angiotensin I Converting Enzyme expressed in: E.coli |
Recombinant Angiotensin I Converting Enzyme (ACE) |
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4-RPA004Mu02 | Cloud-Clone |
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Description: Recombinant Mouse Angiotensin I Converting Enzyme expressed in: E.coli |
Recombinant Angiotensin I Converting Enzyme (ACE) |
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4-RPA004Mu03 | Cloud-Clone |
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Description: Recombinant Mouse Angiotensin I Converting Enzyme expressed in: E.coli |
Recombinant Angiotensin I Converting Enzyme (ACE) |
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4-RPA004Po01 | Cloud-Clone |
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Description: Recombinant Pig Angiotensin I Converting Enzyme expressed in: E.coli |
Recombinant Angiotensin I Converting Enzyme (ACE) |
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4-RPA004Rb01 | Cloud-Clone |
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Description: Recombinant Rabbit Angiotensin I Converting Enzyme expressed in: E.coli |
Active Angiotensin I Converting Enzyme (ACE) |
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4-APA004Hu02 | Cloud-Clone |
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Description: Recombinant Human Angiotensin I Converting Enzyme expressed in: Available from E.coli, Yeast, Baculovirus and Mammalian cells |
Monoclonal Angiotensin Converting Enzyme 1 Antibody |
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APG01871G | Leading Biology | 0.1ml | EUR 484 |
Description: A Monoclonal antibody against Human Angiotensin Converting Enzyme 1. The antibodies are raised in Mouse. This antibody is applicable in WB |
Angiotensin I Converting Enzyme (ACE) Antibody |
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20-abx128667 | Abbexa |
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Angiotensin I Converting Enzyme (ACE) Antibody |
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20-abx129494 | Abbexa |
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Angiotensin I Converting Enzyme (ACE) Antibody |
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20-abx129607 | Abbexa |
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Angiotensin-Converting Enzyme 2 (ACE2) Antibody |
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20-abx313823 | Abbexa |
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Angiotensin I Converting Enzyme (ACE) Antibody |
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20-abx103103 | Abbexa |
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Angiotensin I Converting Enzyme (ACE) Antibody |
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20-abx103104 | Abbexa |
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Angiotensin I Converting Enzyme (ACE) Antibody |
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20-abx103105 | Abbexa |
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Angiotensin I Converting Enzyme (ACE) Antibody |
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abx037354-100ug | Abbexa | 100 ug | EUR 391 |
Angiotensin I Converting Enzyme (ACE) Antibody |
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abx140499-01mg | Abbexa | 0.1 mg | EUR 356 |
Angiotensin I Converting Enzyme (ACE) Antibody |
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20-abx007362 | Abbexa |
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Angiotensin I Converting Enzyme (ACE) Antibody |
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abx025482-100ul | Abbexa | 100 ul | EUR 523 |
Angiotensin I Converting Enzyme (ACE) Antibody |
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abx033685-400ul | Abbexa | 400 ul | EUR 523 |
Angiotensin I Converting Enzyme (ACE) Antibody |
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abx033685-80l | Abbexa | 80 µl | EUR 286 |
Angiotensin-Converting Enzyme (CD143) Antibody (FITC) |
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abx413654-01mg | Abbexa | 0.1 mg | EUR 578 |
Angiotensin I Converting Enzyme (ACE) Antibody |
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20-abx270178 | Abbexa |
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Angiotensin I Converting Enzyme (ACE) Antibody |
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20-abx270179 | Abbexa |
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Angiotensin I-Converting Enzyme Substrate Peptide |
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20-abx265670 | Abbexa |
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Angiotensin I Converting Enzyme (ACE) Antibody |
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20-abx241080 | Abbexa |
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Angiotensin I Converting Enzyme (ACE) Antibody |
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20-abx241081 | Abbexa |
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Angiotensin I Converting Enzyme (ACE) Antibody |
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abx159297-100ul | Abbexa | 100 ul | EUR 467 |
Angiotensin I Converting Enzyme (ACE) Antibody |
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20-abx241727 | Abbexa |
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Angiotensin I Converting Enzyme (ACE) Antibody |
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20-abx214211 | Abbexa |
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Angiotensin I Converting Enzyme (ACE) Antibody |
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20-abx175391 | Abbexa |
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Angiotensin I Converting Enzyme (ACE) Antibody |
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20-abx175393 | Abbexa |
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Angiotensin I Converting Enzyme (ACE) Antibody |
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20-abx171229 | Abbexa |
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Angiotensin I Converting Enzyme (ACE) Antibody |
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20-abx171230 | Abbexa |
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Angiotensin I Converting Enzyme (ACE) Antibody |
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20-abx171231 | Abbexa |
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Angiotensin I Converting Enzyme (ACE) Antibody |
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20-abx171232 | Abbexa |
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Angiotensin I Converting Enzyme (ACE) Antibody |
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20-abx171233 | Abbexa |
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Angiotensin I Converting Enzyme (ACE) Antibody |
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abx230080-100ug | Abbexa | 100 ug | EUR 481 |
Angiotensin I Converting Enzyme (ACE) Antibody |
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20-abx328371 | Abbexa |
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Angiotensin I Converting Enzyme (ACE) Antibody |
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20-abx325361 | Abbexa |
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Anti-Angiotensin Converting Enzyme 1 antibody |
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STJ99092 | St John's Laboratory | 200 µl | EUR 197 |
Description: Mouse monoclonal to Angiotensin Converting Enzyme 1. |
Angiotensin I-Converting Enzyme (ACE) Inactivator |
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N-1360.0250 | Bachem | 250.0mg | EUR 576 |
Description: Sum Formula: C21H21N3O4; CAS# [144085-32-5] |
Angiotensin I-Converting Enzyme (ACE) Inactivator |
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N-1360.1000 | Bachem | 1.0g | EUR 1663 |
Description: Sum Formula: C21H21N3O4; CAS# [144085-32-5] |
Angiotensin Converting Enzyme 2 Conjugated Antibody |
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C49072 | SAB | 100ul | EUR 397 |
Rat Angiotensin Converting Enzyme ELISA kit |
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E02A2159-192T | BlueGene | 192 tests | EUR 1270 |
Description: A competitive for quantitative measurement of Rat Angiotensin Converting Enzyme in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rat Angiotensin Converting Enzyme ELISA kit |
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E02A2159-48 | BlueGene | 1 plate of 48 wells | EUR 520 |
Description: A competitive for quantitative measurement of Rat Angiotensin Converting Enzyme in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rat Angiotensin Converting Enzyme ELISA kit |
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E02A2159-96 | BlueGene | 1 plate of 96 wells | EUR 685 |
Description: A competitive for quantitative measurement of Rat Angiotensin Converting Enzyme in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Human Angiotensin Converting Enzyme ELISA kit |
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E01A2159-192T | BlueGene | 192 tests | EUR 1270 |
Description: A competitive for quantitative measurement of Human Angiotensin Converting Enzyme in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Human Angiotensin Converting Enzyme ELISA kit |
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E01A2159-48 | BlueGene | 1 plate of 48 wells | EUR 520 |
Description: A competitive for quantitative measurement of Human Angiotensin Converting Enzyme in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Human Angiotensin Converting Enzyme ELISA kit |
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E01A2159-96 | BlueGene | 1 plate of 96 wells | EUR 685 |
Description: A competitive for quantitative measurement of Human Angiotensin Converting Enzyme in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Anti-Angiotensin Converting Enzyme 1 (6A4) |
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YF-MA12650 | Abfrontier | 100 ug | EUR 363 |
Description: Mouse monoclonal to Angiotensin Converting Enzyme 1 |
Anti-Angiotensin Converting Enzyme 1 (4B10) |
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YF-MA12651 | Abfrontier | 100 ug | EUR 363 |
Description: Mouse monoclonal to Angiotensin Converting Enzyme 1 |
Rabbit Angiotensin Converting Enzyme ELISA kit |
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E04A2159-192T | BlueGene | 192 tests | EUR 1270 |
Description: A competitive for quantitative measurement of Rabbit Angiotensin Converting Enzyme in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rabbit Angiotensin Converting Enzyme ELISA kit |
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E04A2159-48 | BlueGene | 1 plate of 48 wells | EUR 520 |
Description: A competitive for quantitative measurement of Rabbit Angiotensin Converting Enzyme in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rabbit Angiotensin Converting Enzyme ELISA kit |
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E04A2159-96 | BlueGene | 1 plate of 96 wells | EUR 685 |
Description: A competitive for quantitative measurement of Rabbit Angiotensin Converting Enzyme in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Mouse Angiotensin Converting Enzyme ELISA kit |
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E03A2159-192T | BlueGene | 192 tests | EUR 1270 |
Description: A competitive for quantitative measurement of Mouse Angiotensin Converting Enzyme in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Mouse Angiotensin Converting Enzyme ELISA kit |
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E03A2159-48 | BlueGene | 1 plate of 48 wells | EUR 520 |
Description: A competitive for quantitative measurement of Mouse Angiotensin Converting Enzyme in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Mouse Angiotensin Converting Enzyme ELISA kit |
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E03A2159-96 | BlueGene | 1 plate of 96 wells | EUR 685 |
Description: A competitive for quantitative measurement of Mouse Angiotensin Converting Enzyme in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Pig Angiotensin Converting Enzyme ELISA kit |
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E07A2159-192T | BlueGene | 192 tests | EUR 1270 |
Description: A competitive for quantitative measurement of Porcine Angiotensin Converting Enzyme in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Pig Angiotensin Converting Enzyme ELISA kit |
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E07A2159-48 | BlueGene | 1 plate of 48 wells | EUR 520 |
Description: A competitive for quantitative measurement of Porcine Angiotensin Converting Enzyme in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Pig Angiotensin Converting Enzyme ELISA kit |
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E07A2159-96 | BlueGene | 1 plate of 96 wells | EUR 685 |
Description: A competitive for quantitative measurement of Porcine Angiotensin Converting Enzyme in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Goat Angiotensin Converting Enzyme ELISA kit |
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E06A2159-192T | BlueGene | 192 tests | EUR 1270 |
Description: A competitive for quantitative measurement of Goat Angiotensin Converting Enzyme in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Goat Angiotensin Converting Enzyme ELISA kit |
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E06A2159-48 | BlueGene | 1 plate of 48 wells | EUR 520 |
Description: A competitive for quantitative measurement of Goat Angiotensin Converting Enzyme in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Goat Angiotensin Converting Enzyme ELISA kit |
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E06A2159-96 | BlueGene | 1 plate of 96 wells | EUR 685 |
Description: A competitive for quantitative measurement of Goat Angiotensin Converting Enzyme in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Dog Angiotensin Converting Enzyme ELISA kit |
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E08A2159-192T | BlueGene | 192 tests | EUR 1270 |
Description: A competitive for quantitative measurement of Canine Angiotensin Converting Enzyme in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Dog Angiotensin Converting Enzyme ELISA kit |
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E08A2159-48 | BlueGene | 1 plate of 48 wells | EUR 520 |
Description: A competitive for quantitative measurement of Canine Angiotensin Converting Enzyme in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Dog Angiotensin Converting Enzyme ELISA kit |
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E08A2159-96 | BlueGene | 1 plate of 96 wells | EUR 685 |
Description: A competitive for quantitative measurement of Canine Angiotensin Converting Enzyme in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Monkey Angiotensin Converting Enzyme ELISA kit |
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E09A2159-192T | BlueGene | 192 tests | EUR 1270 |
Description: A competitive for quantitative measurement of Monkey Angiotensin Converting Enzyme in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Monkey Angiotensin Converting Enzyme ELISA kit |
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E09A2159-48 | BlueGene | 1 plate of 48 wells | EUR 520 |
Description: A competitive for quantitative measurement of Monkey Angiotensin Converting Enzyme in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Monkey Angiotensin Converting Enzyme ELISA kit |
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E09A2159-96 | BlueGene | 1 plate of 96 wells | EUR 685 |
Description: A competitive for quantitative measurement of Monkey Angiotensin Converting Enzyme in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Recombinant Angiotensin I Converting Enzyme 2 (ACE2) |
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4-RPB886Mu01 | Cloud-Clone |
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Description: Recombinant Mouse Angiotensin I Converting Enzyme 2 expressed in: E.coli |
Recombinant Angiotensin I Converting Enzyme 2 (ACE2) |
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4-RPB886Ra01 | Cloud-Clone |
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Description: Recombinant Rat Angiotensin I Converting Enzyme 2 expressed in: E.coli |
Rat Angiotensin converting enzyme, ACE ELISA Kit |
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CSB-E04490r-24T | Cusabio | 1 plate of 24 wells | EUR 165 |
Description: Quantitativecompetitive ELISA kit for measuring Rat Angiotensin converting enzyme, ACE in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price. |
Rat Angiotensin converting enzyme, ACE ELISA Kit |
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1-CSB-E04490r | Cusabio |
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Description: Quantitativecompetitive ELISA kit for measuring Rat Angiotensin converting enzyme, ACE in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits. |
Mouse Angiotensin converting enzyme, ACE ELISA Kit |
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CSB-E04492m-24T | Cusabio | 1 plate of 24 wells | EUR 165 |
Description: Quantitative sandwich ELISA kit for measuring Mouse Angiotensin converting enzyme, ACE in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price. |
Mouse Angiotensin converting enzyme, ACE ELISA Kit |
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1-CSB-E04492m | Cusabio |
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Description: Quantitative sandwich ELISA kit for measuring Mouse Angiotensin converting enzyme, ACE in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits. |
Rat Angiotensin converting enzyme(ACE)ELISA Kit |
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GA-E0666RT-48T | GenAsia Biotech | 48T | EUR 317 |
Rat Angiotensin converting enzyme(ACE)ELISA Kit |
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GA-E0666RT-96T | GenAsia Biotech | 96T | EUR 496 |
Mouse Angiotensin converting enzyme(ACE)ELISA Kit |
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GA-E0038MS-48T | GenAsia Biotech | 48T | EUR 336 |
Mouse Angiotensin converting enzyme(ACE)ELISA Kit |
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GA-E0038MS-96T | GenAsia Biotech | 96T | EUR 534 |
Human Angiotensin converting enzyme(ACE)ELISA Kit |
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GA-E0944HM-48T | GenAsia Biotech | 48T | EUR 289 |
Human Angiotensin converting enzyme(ACE)ELISA Kit |
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GA-E0944HM-96T | GenAsia Biotech | 96T | EUR 466 |
Anti-Angiotensin Converting Enzyme 1/ACE Antibody |
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PA2196-1 | BosterBio | 100ug/vial | EUR 334 |
Anti-Angiotensin Converting Enzyme 1/ACE Antibody |
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PA2196-2 | BosterBio | 100ug/vial | EUR 294 |